Prostate Home > Jalyn Warnings and Precautions

It's important to be aware of Jalyn's safety warnings and precautions before taking the medication. For example, this drug can cause sexual side effects, low blood pressure, and priapism. To avoid potential complications, make sure your healthcare provider is aware of any health conditions you have, such as liver problems, an allergy to sulfa medications, or a history of low blood pressure.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Jalyn™ (dutasteride/tamsulosin) if you have:
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings for Jalyn

Some warnings and precautions to be aware of prior to taking this drug include the following:
  • Before you start treatment with Jalyn, and while you are taking it, your healthcare provider may check to make sure your enlarged prostate symptoms are not caused by another condition, such as prostate cancer or bladder problems.
  • Sometimes, a blood test called a prostate-specific antigen (PSA) test is used to check for prostate cancer (see Prostate Cancer Screening). Jalyn can lower your PSA levels in the blood. Your healthcare provider will adjust your PSA test result if you are taking Jalyn, or he or she may use a slightly different test called the percent-free PSA. Any increase in PSA while taking Jalyn (even if still within the normal range) should be further evaluated, as this may be a possible sign of prostate cancer.


  • Studies have shown that dutasteride (one of the active ingredients in Jalyn) may increase the risk of a serious type of prostate cancer. You should discuss this risk with your healthcare provider, especially if you have a family history of prostate cancer. Interestingly, dutasteride appears to decrease the risk of less serious prostate cancers.
  • You should not donate blood while taking Jalyn or for at least six months after you stop taking this medicine. The reason for this is to prevent pregnant women from being exposed to Jalyn through donated blood.
  • If you have liver problems, including liver failure or cirrhosis, you should talk with your healthcare provider before taking Jalyn. The liver helps remove Jalyn from the body, so the medication could accumulate in people who have liver problems.
  • Men with severely decreased urine flow, or men who can only empty very little of their bladder at a time, should be closely monitored by their healthcare providers. Jalyn may not be the best option for these men.
  • Jalyn can cause a sudden decrease in blood pressure (hypotension), especially when sitting or standing up. This may lead to fainting, dizziness, or feeling lightheaded. This side effect is more common when Jalyn is first started.

If you experience any of these symptoms, make sure to avoid situations that might be dangerous, such as driving or operating heavy machinery. It may also be a good idea to sit or stand up slowly. Make sure to tell your healthcare provider if you have any of these symptoms.

  • Very rarely, Jalyn can cause a condition called priapism, a painful erection of the penis that does not go away. If you experience an erection for longer than four hours while taking Jalyn, seek immediate medical attention. Although it may seem embarrassing, if not treated immediately, priapism may lead to permanent damage to the penis and impotency.
  • Jalyn can cause a condition called intraoperative floppy iris syndrome, a problem with the eyes that can occur during cataract surgery. This problem can occur if you currently take Jalyn or if you have taken it in the past. Before having eye surgery, make sure to tell your healthcare provider if you are or have ever been on Jalyn.
  • Although it is very rare, people who have a sulfa allergy might also be allergic to Jalyn. If you have a sulfa allergy that has caused severe or life-threatening reactions in the past, talk with your healthcare provider before taking Jalyn.



  • Jalyn can cause sexual side effects, including a decreased libido (sex drive), erectile dysfunction (ED or impotence), and a decreased ejaculate amount. Men taking Jalyn may also have reduced sperm counts during treatment and for at least 24 weeks after stopping this medication. It is currently unknown if this reduced sperm count affects fertility (see Jalyn Sexual Side Effects).
  • Jalyn is considered a pregnancy Category X medication. This means that it is very dangerous for use during pregnancy. Women who are pregnant or who may become pregnant should not take Jalyn or even touch Jalyn capsules (see Jalyn and Pregnancy).
  • It is unknown if Jalyn passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, discuss this with your healthcare provider prior to taking the drug (see Jalyn and Breastfeeding). It's important to remember that this medication is not approved for use in women.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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