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Rapaflo Interactions
A number of medications may cause negative Rapaflo interactions, including blood pressure medicines and certain antibiotics or antifungals. Drug interactions with Rapaflo could increase your risk of developing side effects, including dangerously low blood pressure. In order to help prevent these interactions, you should tell your healthcare provider about all other medications you are taking before starting Rapaflo.
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Rapaflo™ (silodosin) can potentially interact with several other medications. Some of these medicines that may lead to Rapaflo drug interactions include:
- Blood pressure medications
- Certain antibiotics or antifungals, including:
- Clarithromycin (Biaxin®)
- Erythromycin (Ery-Tab®)
- Fluconazole (Diflucan®)
- Isoniazid (Nydrazid®)
- Itraconazole (Sporanox®)
- Ketoconazole (Nizoral®)
- Miconazole
- Telithromycin (Ketek®)
- Voriconazole (VFEND®)
- Amprenavir (Agenerase®)
- Atazanavir (Reyataz®)
- Darunavir (Prezista®)
- Delavirdine (Rescriptor®)
- Fosamprenavir (Lexiva®)
- Indinavir (Crixivan®)
- Nelfinavir (Viracept®)
- Ritonavir (Norvir®)
- Saquinavir (Invirase®)
- Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
- Imatinib (Gleevec®)
- Nefazodone (Serzone®)
- Nicardipine (Cardene®)
- Other alpha blockers similar to Rapaflo, including:
- Alfuzosin (Uroxatral®)
- Carvedilol (Coreg®)
- Doxazosin (Cardura®)
- Labetalol (Trandate®)
- Methyldopa
- Phenoxybenzamine (Dibenzyline®)
- Phentolamine (Regitine®)
- Prazosin (Minipress®)
- Tamsulosin (Flomax®)
- Terazosin (Hytrin®)
- Phosphodiesterase type 5 inhibitors (PDE5 inhibitors), including:
- Quinidine.
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD



